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Anaesthesia


Title:Minimum local analgesic concentration of ropivacaine for intra-operative caudal analgesia in pre-school and school age children
Author(s):Deng, X. M. Xiao, W. J. Tang, G. Z. Luo, M. P. Xu, K. L.
Address:Professor, Professor, Staff Anaesthesiologist , Associate Professor, Department of Anaesthesiology, Plastic Surgery Hospital, Staff Anaesthesiologist, Department oAnaesthesiology, Cardiovascular Institute & Fuwai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Year:2010 Jul 26
Journal Title:Anaesthesia
Page Number:
Language:ENG
Volume:
Issue:
ISSN/ISBN:1365-2044 (Electronic). 0003-2409 (Linking)
Abstract:Summary We compared the minimum local analgesia concentration of ropivacaine for intra-operative caudal analgesia in pre-school and school age children. Fifty-one boys, undergoing hypospadius repair surgery, were stratified into pre-school or school age groups. After induction of anaesthesia, caudal block was performed with ropivacaine 1 ml.kg(-1) of the desired concentration. The first child in each group received ropivacaine 0.125%, and subsequent concentrations were determined by the analgesic response of the previous patient using Dixon's up-and-down method. Under general anaesthesia with 0.7 minimum alveolar concentration of sevoflurane, the minimum local analgesia concentration of ropivacaine for intra-operative caudal block was 34% greater in school age than in pre-school age boys (0.143% (95% CI 0.132-0.157%) vs 0.107% (95% CI 0.089-0.122%), respectively; p < 0.001). This study indicates that a higher concentration of ropivacaine is needed for school age than pre-school age children to provide intra-operative caudal analgesia when combined with general anaesthesia.

 
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