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Adv Myocardiol

Title:		Epicardial image analysis using a desk top computer. Comparison of epicardial flow distribution and NADH-fluorescence pattern
Author(s):		Roesen, R. Panzner, B. Klaus, W.
Address:
Year:		1985
Journal Title:		Adv Myocardiol
Page Number:		217-31
Language:		eng
Volume:		6
Issue:
ISSN/ISBN:		0270-4056 (Print). 0270-4056 (Linking)
Abstract:		In isolated coronary-ligated rabbit hearts, quantification of epicardial flow distribution pattern and of ischemic area was performed from flow indicator and endogenous NADH-fluorescence pictures, respectively, after UV-flash photography. After being digitized (256 X 256 pixels), the fluorescence photos were analyzed by an Apple desk computer using self-written software (fast machine routines called from BASIC programs). The ischemic area (= sum of pixels with enhanced NADH fluorescence) corresponds to the area with disturbed coronary perfusion (= sum of pixels with diminished indicator fluorescence). Since coronary-active drugs might affect both parameters--local myocardial perfusion and metabolism--differentially, the method presented seems to be a very useful technique for differentiated analysis of the action profile of coronary-active drugs.