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Anaesthesia


Title:A comparison of the effect on QT interval between thiamylal and propofol during anaesthetic induction*
Author(s):Higashijima, U. Terao, Y. Ichinomiya, T. Miura, K. Fukusaki, M. Sumikawa, K.
Address:Staff, Department of Anaesthesia, Nagasaki Rosai Hospital, Sasebo, Japan.
Year:2010 Jul
Journal Title:Anaesthesia
Page Number:679-83
Language:eng
Volume:65
Issue:7
ISSN/ISBN:1365-2044 (Electronic). 0003-2409 (Linking)
Abstract:SUMMARY: The aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected QT (QTc) interval during anaesthetic induction. We studied 50 patients undergoing lumbar spine surgery. Patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. Tracheal intubation was performed after vecuronium administration. Heart rate, mean arterial pressure, bispectral index score, and 12-lead electrocardiogram were recorded at the following time points: just before (T1) and 2 min after (T2) fentanyl administration; 2 min after anaesthetic administration (T3); 2.5 min after vecuronium injection (T4); and 2 min after intubation (T5). Thiamylal prolonged (p < 0.0001), but propofol shortened (p < 0.0001), the QTc interval.

 
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