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Anaesthesia


Title:Differential effects of propofol and isoflurane on the activation of T-helper cells in lung cancer patients
Author(s):Ren, X. F. Li, W. Z. Meng, F. Y. Lin, C. F.
Address:Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Year:2010 May
Journal Title:Anaesthesia
Page Number:478-82
Language:eng
Volume:65
Issue:5
ISSN/ISBN:1365-2044 (Electronic). 0003-2409 (Linking)
Abstract:It is suggested that activation and differentiation of T-helper cells are required for peri-operative anti-tumor and anti-infection immunity. The present study aimed to evaluate whether propofol stimulates the activation and differentiation of these cells in patients undergoing pulmonary lobectomy for non-small-cell lung cancer. Thirty patients were randomly allocated to receive propofol or isoflurane throughout surgery. The CD4(+)CD28(+) percentage (p < 0.0001) and the ratio of interferon-gamma:interleukin-4 (p = 0.001) all increased with propofol but showed no change with isoflurane. In contrast, cortisol increased with isoflurane (p < 0.0001) but not with propofol over time (p = 0.06). We conclude that propofol promotes activation and differentiation of peripheral T-helper cells.

 
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