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Anaesthesia


Title:Increased formation of sister chromatid exchanges, but not of micronuclei, in anaesthetists exposed to low levels of sevoflurane
Author(s):Wiesner, G.Schiewe-Langgartner, F.Lindner, R.Gruber, M.
Address:Department of Anaesthesiology, German Heart Centre Munich, Germany. wiesner@dhm.mhn.de
Year:2008 Aug
Journal Title:Anaesthesia
Page Number:861-4
Language:eng
Volume:63
Issue:8
ISSN/ISBN:1365-2044 (Electronic). 0003-2409 (Linking)
Abstract:We have assessed, for the first time, genotoxicity (i.e. sister chromatid exchanges and micronuclei) in anaesthetists exposed to a single volatile anaesthetic (sevoflurane) without nitrous oxide. The anaesthetists were exposed to an 8-h time-weighted average of 0.2 parts per million sevoflurane. Internists served as non-exposed controls. Mean (SD) sister chromatid exchanges per cell were significantly higher in anaesthetists compared to internists (6.6 (0.9) vs 5.1 (0.8); p < 0.001) whereas median (IQR [range]) micronuclei per 1000 binucleated cells did not differ (9.5 (6.3-10.8 [2.0-15.5]) vs 8.5 (6.0-10.5 [3.0-25.5]), respectively). Although the anaesthetists were exposed to rather low concentrations of sevoflurane, this 30% increase of sister chromatid exchanges is in agreement with a recently reported 300% increase with a high level exposure to sevoflurane and nitrous oxide. Omitting nitrous oxide does not normalise increased rates of sister chromatid exchanges.

 
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