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Anaesthesia


Title:A comparison of 8% and 12% sevoflurane for inhalation induction in adults
Author(s):Goodwin, N.Campbell, A. E.Hall, J. E.Plummer, S.Harmer, M.
Address:Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, UK. godwinn1@cf.ac.uk
Year:2004 Jan
Journal Title:Anaesthesia
Page Number:15-Sep
Language:eng
Volume:59
Issue:1
ISSN/ISBN:0003-2409 (Print). 0003-2409 (Linking)
Abstract:Sevoflurane is a non-pungent volatile anaesthetic agent with a low blood-gas solubility coefficient. It has been studied in concentrations of up to 8% for induction of anaesthesia. Previous work has suggested that there may be a ceiling effect with increasing concentration of sevoflurane above 6%, but there are no published studies using 12% sevoflurane. This study compared 8 and 12% sevoflurane to induce anaesthesia in adults. Sevoflurane was administered using two adapted datum vaporisers with the interlock removed. Induction with 12% sevoflurane compared to 8% sevoflurane produced a significant decrease in the time to achieve central pupils, corresponding to surgical anaesthesia and the third part of Guedel's stage 3 of anaesthesia (mean time (SD) 201 s (81) and 247 s (39), respectively, p < 0.05). Twelve-percent sevoflurane produced a similar stable cardiovascular profile to 8% sevoflurane, and there was no increase in respiratory complications.

 
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