ISCATECH   Bedoukian   RussellIPM   Piezoelectric Micro-Sprayer


Home
Animal Taxa
Plant Taxa
Semiochemicals
Floral Compounds
Semiochemical Detail
Semiochemicals & Taxa
Synthesis
Control
Invasive spp.
References

Abstract

Guide

Chemtica
Biochemtech
AlphaScents
U-Chemo
BIOHOME
Print
Email to a Friend
Kindly Donate for The Pherobase

« Previous AbstractCharacteristics and toxicological processing of postmortem pilot specimens* from fatal civil aviation accidents    Next AbstractCaring less, doing more: the role of therapeutic detachment with volatile and unmotivated clients »

Anaesthesia


Title:The effects of sevoflurane and desflurane in vitro on platelet-leukocyte adhesion in whole blood
Author(s):Horn, N. A.de Rossi, L.Robitzsch, T.Hecker, K. E.Hutschenreuter, G.Rossaint, R.
Address:Department of Anaesthesiology, Rheinisch-Westfalische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. nhorn@ukaachen.de
Year:2003 Apr
Journal Title:Anaesthesia
Page Number:312-9
Language:eng
Volume:58
Issue:4
ISSN/ISBN:0003-2409 (Print). 0003-2409 (Linking)
Abstract:The interaction between platelets and leukocytes plays an important role in inflammatory and thrombotic processes. We investigated whether the volatile anaesthetics sevoflurane and desflurane alter the formation of platelet-leukocyte aggregates and the expression of P-selectin on platelets. Whole blood was incubated with 1 and 2 minimum alveolar concentration (MAC) sevoflurane or desflurane. Unstimulated and adenosine diphosphate, or thrombin receptor agonist peptide-6-stimulated samples were stained with fluorochrome-conjugated antibodies. The formation of platelet-leukocyte conjugates and the expression of P-selectin on platelets were measured using flow cytometry. Sevoflurane was found to enhance the binding of platelets to lymphocytes, neutrophils and monocytes, it also increased the expression of P-selectin on platelets especially in the stimulated samples. Desflurane decreased the percentage of lymphocyte-platelet, neutrophil-platelet and monocyte-platelet conjugates principally in unstimulated samples. The results show that these two volatile anaesthetics have differing effects on the formation of platelet-leukocyte conjugates in vitro. Sevoflurane also enhanced the expression of P-selectin on platelets.

 
Back to top
 
Citation: El-Sayed AM 2021. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2021 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 15-01-2021