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Anaesthesia


Title:Physicochemical properties and pharmacodynamics of desflurane
Author(s):Eger, E. I. 2nd
Address:Department of Anesthesia, University of California, San Francisco 94143-0648, USA.
Year:1995 Oct
Journal Title:Anaesthesia
Page Number:08-Mar
Language:eng
Volume:50 Suppl
Issue:
ISSN/ISBN:0003-2409 (Print). 0003-2409 (Linking)
Abstract:Desflurane is a new volatile, inhaled anaesthetic that differs significantly from presently available inhaled agents in being halogenated solely with fluorine. This fluorination produces a lower solubility and increased resistance to biodegradation. The lower solubility provides a more precise control over, and a more rapid awakening from, anaesthesia. The resistance to biodegradation suggests that toxicity from desflurane may be minimal or non-existent. Limitations include a lesser potency and greater pungency at concentrations exceeding 1 minimum alveolar concentration (MAC). Other pharmacological properties are similar to those of isoflurane.

 
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