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Anaesthesia

Title:		Isoflurane and propofol for long-term sedation in the intensive care unit. A crossover study
Author(s):		Millane, T. A.Bennett, E. D.Grounds, R. M.
Address:		Department of Intensive Care, St George's Hospital, London.
Year:		1992 Sep
Journal Title:		Anaesthesia
Page Number:		768-74
Language:		eng
Volume:		47
Issue:		9
ISSN/ISBN:		0003-2409 (Print). 0003-2409 (Linking)
Abstract:		Propofol and isoflurane have been reported recently to offer better sedation than alternative agents in patients who require long-term ventilation in the Intensive Care Unit. This is the first report of a direct comparison between propofol and isoflurane. Twenty-four patients predicted to require artificial ventilation for at least 48 h were entered into a randomised crossover study to monitor sedation quality and time to recovery from sedation. There were no significant differences between the two agents in either end-point, with over 95% optimal sedation achieved by the use of each drug. Few adverse events were noted. Technological advances in the administration of volatile agents as long-term sedatives in the Intensive Care Unit may facilitate their more widespread use.